The 1,341-acre White Clay Creek Preserve is in southern Chester County, three miles north of Newark, Delaware. The White Clay Creek Valley, which forms the core of the Preserve, varies from steep to gradually falling terrain with some flat bottomlands. White Clay Creek Preserve shares boundary with White Clay Creek State Park of Delaware.

Because White Clay Creek posses outstanding scenic, wildlife, recreational and cultural value, it has been designated by Congress as a National Wild and Scenic River, and shall be preserved in free-flowing condition for the benefit and enjoyment of present and future generations.